DOI
https://doi.org/10.18849/ve.v4i2.183Abstract
PICO question
In dogs with generalised demodicosis, are isoxazolines as effective as a combined formulation of imidacloprid and moxidectin at reducing mite count and the severity of associated clinical signs?
Clinical bottom line
Five single-blinded, randomised, positive control trials, most under laboratory conditions, directly compared the use of isoxazolines against moxidectin/imidacloprid to treat canine generalised demodicosis. All of them showed comparable efficacy of isoxazolines. Three different isoxazolines were studied with two routes of administration (oral and topical) and four different dosing frequencies of moxidectin/imidacloprid. This made the papers more challenging to compare however, the evidence provided is sufficient to support their use. All of these trials were sponsored by the manufacturers of their respective isoxazoline products which may bias the study design and reporting of results. It is worth noting that sarolaner (Simparica™, Zoetis UK) was licensed in the UK for the treatment of canine demodicosis in January 2018 and that in the UK the Cascade should be followed when prescribing treatments. The licensed use of isoxazolines in other countries is beyond the scope of this article and the reader is urged to check local regulatory body advice before prescribing the below medications.
References
Becskei, C., Cuppens, O., & Mahabir, S. P. (2018). Efficacy and safety of sarolaner against generalized demodicosis in dogs in European countries: A non-inferiority study. Veterinary Dermatology, 1–7. https://doi.org/10.1111/vde.12526
Beugnet, F., Halos, L., Larsen, D., & de Vos, C. (2016). Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis. Parasite, 23, 14. https://doi.org/10.1051/parasite/2016014
Fourie, J. J., Liebenberg, J. E., Horak, I. G., Taenzler, J., Heckeroth, A. R., & Frénais, R. (2015). Efficacy of orally administered fluralaner (Bravecto®) or topically applied imidacloprid/moxidectin (Advocate®) against generalized demodicosis in dogs. Parasites and Vectors, 8(1), 1–8. https://doi.org/10.1186/s13071-015-0775-8
Fourie, J. J., Meyer, L., & Thomas, E. (2019). Efficacy of topically administered fluralaner or imidacloprid/moxidectin on dogs with generalised demodicosis. Parasites and Vectors. https://doi.org/10.1186/s13071-018-3230-9
Mueller, R. S., Bensignor, E., Ferrer, L., Holm, B., Lemarie, S., Paradis, M., & Shipstone, M. A. (2012). Treatment of demodicosis in dogs: 2011 clinical practice guidelines. Veterinary Dermatology, 23(2). https://doi.org/10.1111/j.1365-3164.2011.01026.x
Perego, R., Spada, E., Foppa, C., & Proverbio, D. (2019). Critically appraised topic for the most effective and safe treatment for canine generalised demodicosis. BMC Veterinary Research. https://doi.org/10.1186/s12917-018-1767-7
Six, R. H., Becskei, C., Mazaleski, M. M., Fourie, J. J., Mahabir, S. P., Myers, M. R., & Slootmans, N. (2016). Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis. Veterinary Parasitology, 222, 62–66. https://doi.org/10.1016/j.vetpar.2016.02.027
License
Veterinary Evidence uses the Creative Commons copyright Creative Commons Attribution 4.0 International License. That means users are free to copy and redistribute the material in any medium or format. Remix, transform, and build upon the material for any purpose, even commercially - with the appropriate citation.
Most read articles by the same author(s)
- Sarah Long, Managing atopic dermatitis in dogs: are antihistamines as effective as glucocorticoids? , Veterinary Evidence: Vol. 5 No. 4 (2020): The fourth issue of 2020
