DOI
https://doi.org/10.18849/ve.v7i2.509Abstract
PICO question
In adult dairy cows with ovarian follicular cysts, does treatment with gonadotropin-releasing hormone (GnRH) compared to human chorionic gonadotropin (hCG) result in a more rapid return to cyclicity?
Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
The publications consisted of six non-blinded randomised comparative or controlled trials
Strength of evidence
Weak
Outcomes reported
Recovery time, clinical cure, and interval to conception were consistently evaluated. Many studies also evaluated other fertility parameters such as first estrus or first treatment conception, overall pregnancy and conception risks, and breedings per conception
Conclusion
At this time, there is insufficient evidence to suggest whether GnRH or hCG is more efficacious for treating ovarian follicular cysts in dairy cattle. Ultimately, further research is essential to elucidate which treatment results in a more rapid return to cyclicity for dairy cattle afflicted with cystic ovarian follicles
How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
References
Amweg, A. N., Salvetti, N. R., Stangaferro, M. L., Paredes, A. H., Lara, H. H., Rodríguez, F. M. & Ortega, H. H. (2013). Ovarian localization of 11β-hydroxysteroid dehydrogenase (11βHSD): effects of ACTH stimulation and its relationship with bovine cystic ovarian disease. Domestic Animal Endocrinology. 45(3), 126–140. DOI: https://doi.org/10.1016/j.domaniend.2013.07.001
De Rensis, F., Bottarelli, E., Battioni, F., Capelli, T., Techakumphu, M., García-Ispierto, I. & López-Gatius, F. (2008). Reproductive performance of dairy cows with ovarian cysts after synchronizing ovulation using GnRH or hCG during the warm or cool period of the year. Theriogenology. 69(4), 481–484. DOI: https://doi.org/10.1016/j.theriogenology.2007.10.018
De Rensis, F., López-Gatius, F., Garcia-Ispierto, I. & Techakumpu M. (2010). Clinical use of human chorionic gonadotropin in dairy cows: an update. Theriogenology. 73(8), 1001–1008. DOI: https://doi.org/10.1016/j.theriogenology.2009.11.027
Elmore, R. G., Bierschwal, C. J., Youngquist, R. S., Cantley, T. C., Kesler, D. J. & Garverick, H. A. (1975). Clinical responses of dairy cows with ovarian cysts after treatment with 10,000 IU HCG or 100 mcg GnRH. Veterinary Medicine, Small Animal Clinician. 70(11), 1346–1349.
Farin, P. W., Youngquist, R. S., Parfet, J. R. & Garverick, H. A. (1992). Diagnosis of luteal and follicular ovarian cysts by palpation per rectum and linear-array ultrasonography in dairy cows. Journal of the American Veterinary Medical Association. 200(8), 1085–1089.
Garverick, H. A., Kesler, D. J., Cantley, T. C., Elmore, R. G., Youngquist, R. S. & Bierschwal, C. J. (1976). Hormone response of dairy cows with ovarian cysts after treatment with HCG or GnRH. Theriogenology. 6(4), 413–425. DOI: https://doi.org/10.1016/0093-691X(76)90108-4
Garverick, H. A. (1997). Ovarian follicular cysts in dairy cows. Journal of Dairy Science. 80(5), 995–1004. DOI: https://doi.org/10.3168/jds.S0022-0302(97)76025-9
Giordano, J. O., Wiltbank, M. C. & Fricke, P. M. (2012). Humoral immune response in lactating dairy cows after repeated exposure to human chorionic gonadotropin. Theriogenology. 78(1), 218–224. DOI: https://doi.org/10.1016/j.theriogenology.2012.02.003
Gundling, N., Drews, S. & Hoedemaker, M. (2015). Comparison of two different programmes of ovulation synchronization in the treatment of ovarian cysts in dairy cows. Reproduction in Domestic Animals. 50(6), 893–900. DOI: https://doi.org/10.1111/j.1439-0531.2009.01342.x
Howick, J., Chalmers, I., Glasziou, P., Greenhalgh, T., Heneghan, C., Liberati, A., Moschetti, I., Phillips, B. & Thornton, H. (2011). The 2011 Oxford CEBM evidence levels of evidence (introductory document). Oxford Center for Evidence Based Medicine. [online] Available from: https://www.cebm.ox.ac.uk/resources/levels-of-evidence/ocebm-levels-of-evidence [Accessed 05 Aug 2021].
Ijaz, A., Fahning, M. L. & Zemjanis, R. (1987). Treatment and control of cystic ovarian disease in dairy cattle: a review. British Veterinary Journal. 143(3), 226– DOI: https://doi.org/10.1016/0007-1935(87)90085-6
Jeengar, K., Chaudhary, V., Kumar, A., Raiya, S., Gaur, M. & Purohit, G. N. (2014). Ovarian cysts in dairy cows: old and new concepts for definition, diagnosis and therapy. Animal Reproduction. 11(2), 63–73.
Kawate, N., Watanabe, K., Uenaka, K., Takahashi, M., Inaba, T. & Tamada, H. (2011). Comparison of plasma concentrations of estradiol-17β and progesterone, and conception in dairy cows with cystic ovarian diseases between Ovsynch and Ovsynch plus CIDR timed AI protocols. Journal of Reproduction and Development. 57(2), 267–272. DOI: https://doi.org/10.1262/jrd.10-066t
Kesler, D. J. & Garverick, H. A. (1982). Ovarian cysts in dairy cattle: a review. Journal of Animal Science. 55(5), 1147–1159. DOI: https://doi.org/10.2527/jas1982.5551147x
Lean, I. J., Rabiee, A. R., Duffield, T. F. & Dohoo, I. R. (2009). Invited review: Use of meta-analysis in animal health and reproduction: Methods and applications. Journal of Dairy Science. 92(8), 3545–3565. DOI: https://doi.org/10.3168/jds.2009-2140
Liu, T. C., Ho, C. T., Li, K. P., Chang, C. C. & Chan, J. P. W. (2019). Human chorionic gonadotropin (hCG)-induced ovulation occurs later but with equal occurrence in lactating dairy cows: comparing hCG and gonadotropin-releasing hormone protocols. Journal of Reproductive Development. 65(6): 507–514. DOI: https://doi.org/10.1262/jrd.2019-037
Mollo, A., Stradaioli, G., Gloria, A. & Cairoli, F. (2012). Efficacy of different ovarian cysts treatments (GnRH, hCG and PRID) in dairy cows. Journal of Animal and Veterinary Advances. 11(21), 4058–4063. DOI: https://doi.org/10.3923/javaa.2012.4058.4063
Nakao, T., Tsurubayashi, M., Horiuchi, S., Nomura, T., Ishibashi, Y., Kubo, M. & Kawata, K. (1979). Effects of a systematic application of human chorionic gonadotropin, gonadotropin-releasing hormone analog and bovine anterior pituitary gonadotropin in cows with cystic ovarian disease. Theriogenology. 11(5), 385–397. DOI: https://doi.org/10.1016/0093-691X(79)90062-1
Nakao, T., Kawata, K. & Numata Y. (1980). Therapeutic effects of an analog of luteinizing hormone-releasing hormone (Des-Gly10-LH-RH-Ethylamide) on cows with cystic ovary. The Japanese Journal of Veterinary Science. 42(4), 459–462. DOI: https://doi.org/10.1292/jvms1939.42.459
Nakao, T., Tomita, M., Kanbayashi, H., Takagi, H., Abe, T., Takeuchi, Y., Ociai, H., Moriyoshi, M. & Kawata, K. (1992). Comparisons of several dosages of a GnRH analog with the standard dose of hCG in the treatment of follicular cysts in dairy cows. Theriogenology. 38(1), 137–145. DOI: https://doi.org/10.1016/0093-691X(92)90225-G
Ngategize, P. K., Kaneene, J. B., Harsh, S. B., Bartlett, P. C. & Mather, E. L. (1987). A financial analysis of alternative management strategies of cystic follicles. Preventive Veterinary Medicine. 4(5–6), 463–470. DOI: https://doi.org/10.1016/0167-5877(87)90031-6
Ono, T., Takagi, M., Kawashima, C., Wijayagunawardane, M. P. B., Vos, P. L. A. M., Taniguchi, M. & Otoi, T. (2018). Comparative effects of different dosages of hCG on follicular development in postpartum dairy cows with cystic ovarian follicles. Frontiers in Veterinary Science. 5, 130. DOI: https://doi.org/10.3389/fvets.2018.00130
Rizzo, A., Campanile, D., Mutinati, M., Minoia, G., Spedicato, M. & Sciorsci, R. L. (2011). Epidural vs intramuscular administration of lecirelin, a GnRH analogue, for the resolution of follicular cysts in dairy cows. Animal Reproduction Science. 126(1–2), 19–22. DOI: https://doi.org/10.1016/j.anireprosci.2011.04.013
Seguin, B. E., Convey, E. M. & Oxender, W. D. (1976). Effect of gonadotropin-releasing hormone and human chorionic gonadotropin on cows with ovarian follicular cysts. American Journal of Veterinary Research. 37(2), 153–157.
Silvia, W. J., Hatler, T. B., Nugent, A. M. & Da Fonseca, L. L. (2002). Ovarian follicular cysts in dairy cows: an abnormality in folliculogenesis.Domestic Animal Endocrinology. 23(1–2), 167–177. DOI: https://doi.org/10.1016/S0739-7240(02)00154-6
Singh, J., Ghuman, S. P. S. & Honparkhe, M. (2012). Reproductive performance following GNRH or HCG and PGF2α administration in crossbred cattle with ovarian cysts. Veterinary Practitioner. (1), 57–59.
Taktaz, T., Kafi, M., Mokhtari, A. & Heidari, M. (2015). Reproductive responses of dairy cows with ovarian cysts to simultaneous human chorionic gonadotropin or gonadotropin-releasing hormone and cloprostenol compared to gonadotropin-releasing hormone alone treatment. Veterinary World. 8(5), 640–644. DOI: https://doi.org/10.14202/vetworld.2015.640-644
Vanholder, T., Opsomer, G. & De Kruif, A. (2006). Aetiology and pathogenesis of cystic ovarian follicles in dairy cattle: a review. Reproduction Nutrition Development. 46(2), 105–119. DOI: https://doi.org/10.1051/rnd:2006003
Verma, M.C. & Dabas, Y.P.S. (1994). Treatment of ovarian cysts in cows. Indian Journal of Animal Reproduction: Journal of the Indian Society for the Study of Animal Reproduction. 15(2), 125–126.
Wiltbank, M. C., Gümen, A. & Sartori, R. (2002). Physiological classification of anovulatory conditions in cattle. Theriogenology. 57(1), 21–52. DOI: https://doi.org/10.1016/s0093-691x(01)00656-2
Yotov, S. A., Atanasov, A. S., Georgiev, G. B., Dineva, J. D. & Palova, N. A. (2014). Investigation on some biochemical parameters and effect of hormonal treatment in anoestrous dairy cows with cystic ovarian follicle. Asian Pacific Journal of Reproduction. 3(1), 41–45. DOI: https://doi.org/10.1016/S2305-0500(13)60183-9
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