Does treatment with clomipramine reduce cat psychogenic alopecia?

Published:

2022-06-29

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DOI

https://doi.org/10.18849/ve.v7i2.573

Abstract

PICO question

In cats with psychogenic alopecia, is overgrooming reduced by the use of clomipramine compared to untreated cats?

 

Clinical bottom line

Category of research question

Treatment

The number and type of study designs reviewed

One pseudo-randomised controlled study

Strength of evidence

Weak

Outcomes reported

Effect of clomipramine using owner report of number, intensity, and / or duration of grooming episodes, owner reported clinical improvement, and veterinary measured alopecia, extent of tissue damage, and hair regrowth

Conclusion

The only controlled study found no evidence that clomipramine alone is effective in reducing grooming episodes, alopecia, or improved hair regrowth. Further research with randomised, double blind controlled trials and limitation of confounding factors is required to determine the efficacy of clomipramine alone or in addition to behavioural / environmental therapies

 

How to apply this evidence in practice

The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.

Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.

 

Open Access Peer Reviewed

References

Affolter, V.K. & Moore, P.F. (1994). Histologie features of normal canine and feline skin. Clinics in Dermatology. 12(4), 491–497. DOI: https://doi.org/10.1016/0738-081X(94)90215-1

Hendriks, W.H., Tarttelin, M.F. & Moughan, P.J. (1997). Seasonal Hair Growth in the Adult Domestic Cat (Felis catus). Comparative Biochemistry and Physiology Part A: Physiology. 116(1), 29–35. DOI: https://doi.org/10.1016/S0300-9629(96)00113-2

Henssler, J., Heinz, A., Brandt, L. & Bschor, T. (2019). Antidepressant Withdrawal and Rebound Phenomena. Deutsches Ärzteblatt International. 116(20), 355–361. DOI: https://doi.org/10.3238/arztebl.2019.0355

Lainesse, C., Frank, D., Beaudry, F. & Doucet, M. (2007). Effects of physiological covariables on pharmacokinetic parameters of clomipramine in a large population of cats after a single oral administration. Journal of Veterinary Pharmacology and Therapeutics. 30(2), 116–126. DOI: https://doi.org/10.1111/j.1365-2885.2007.00826.x

Luescher, A.U. (2003). Diagnosis and management of compulsive disorders in dogs and cats. Veterinary Clinics of North America: Small Animal Practice. 33(2), 253–267. DOI: https://doi.org/10.1016/S0195-5616(02)00100-6

Mertens, P.A., Torres, S. & Jessen, C. (2006). The Effects of Clomipramine Hydrochloride in Cats With Psychogenic Alopecia: A Prospective Study. Journal of the American Animal Hospital Association. 42(5), 336–343. DOI: https://doi.org/10.5326/0420336

Overall, K.L. & Dunham, A.E. (2002). Clinical features and outcome in dogs and cats with obsessive-compulsive disorder: 126 cases (1989–2000). Journal of the American Veterinary Medical Association. 221(10), 1445–1452. DOI: https://doi.org/10.2460/javma.2002.221.1445

Sawyer, L.S., Moon-Fanelli, A.A. & Dodman, N.H. (1999). Psychogenic alopecia in cats: 11 cases (1993–1996). Journal of the American Veterinary Medical Association. 214(1), 71–74.

Seksel, K. & Lindeman, M.J. (1998). Use of clomipramine in the treatment of anxiety-related and obsessive-compulsive disorders in cats. Australian Veterinary Journal. 76(5), 317–321. DOI: http://dx.doi.org/10.1111/j.1751-0813.1998.tb12353.x

Talamonti, Z., Cannas, S. & Palestrini, C. (2017). A Case of Tail Self-Mutilation in a Cat. Macedonian Veterinary Review. 40(1), 103–107. DOI: http://dx.doi.org/10.1515/macvetrev-2016-0098

Virga, V. (2003). Behavioral dermatology. Veterinary Clinics of North America: Small Animal Practice. 33(2), 231–251. DOI: https://doi.org/10.1016/S0195-5616(02)00102-X

Vol. 7 No. 2 (2022): The second issue of 2022

Section: Knowledge Summaries

Categories :  Small Animal  /  Dogs  /  Cats  /  Rabbits  /  Production Animal  /  Cattle  /  Sheep  /  Pig  /  Equine  / 

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