DOI
https://doi.org/10.18849/ve.v3i1.96Abstract
PICO question
In dogs with naturally occurring multicentric B cell lymphoma does treatment with glucocorticoids alone extend survival time when compared to no treatment?
Clinical bottom line
There is weak evidence, due to insufficient studies with untreated control groups, regarding the impact on survival of prednisolone treatment in dogs with multicentric lymphoma.
From the papers identified from the search functions used for the clinical question remission in uncontrolled trials was reported following prednisolone treatment. Details of which can be found in other sections of this paper.
References
Brick J., Roenigk, W. and Wilson, G. (1968) Chemotherapy of malignant lymphoma in dogs and cats. Journal of the American Veterinary Medical Association 153 (1) 47-52
Mortier,F., Daminet, S., Vandenabeele, S. et al. (2012) Canine lymphoma: a retrospective study (2009-2010). Vlaams Diergeneeskundig Tijdschrift 81 (6) 341-351
Squire, R., Bush, M., Melby, E. et al. (1973) Clinical and pathological study of canine lymphoma: clinical staging, cell classification and therapy. Journal of the National Cancer Institute, 51 (2), 565-74
Tozon, N., Samardzija, P., Prijic, S. et al (2006) Canine lymphoma: cytologic study and response to therapy. Slovenian Veterinary Research 43 (3) 127-133
Valli, V., Kass P., San Myint, M. et al. (2013) Canine lymphomas: association of classification type, disease stage, tumor type, disease stage, tumor subtype, mitotic rate, and treatment with survival. Domestic Mammal Disease 50 (5) 738-748 DOI: http://dx.doi.org/10.1177/0300985813478210
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